Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Abstract

Synthesis and antibacterial properties of newer (2-butyl-5-amino-3-benzofuranyl)-4-methoxy phenyl methanone amino acids

Author(s): Yogesh D B, Dinesh B. Shenoy, Srinivasa G. R, Menaka T, Nagaraja G, and Fazil Baig

The (2-butyl -5-amino-3-benzofuranyl) 4-methoxy phenyl methanone amino acids have been synthesized by the reaction of (2-butyl -5-amino-3-benzofuranyl) 4-methoxy phenyl methanone with different hydrophobic amino acids were described (DBMY1-9). All the compounds were synthesized by conventional method and characterized by IR, 1H NMR and mass spectral data. The synthesized compounds were tested for antimicrobial activity against Staphylococcus aureus, Escherichia coli and pseudomonas aeruginosa. Among the synthesized compounds (2-butyl -5-amino-3-benzofuranyl) 4-methoxy phenyl methanone amino acids (DBMY-3,7,2) was found the most active derivative against S. aureus, E. coli and P. aeruginosa and The compounds DBMY-2, 3, 4 was found the most active derivative against Candida albicans and Asperigillus fumigatus respectively. The other Compounds exhibited moderate activity against the other test microorganisms.


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