Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

Abstract

Synthesis and anticancer activity of novel 2-(4-amino-5-isocyanomethyl- 2,3-dihydro-thiophen-2-yl)-7-[hydroxy-3-methyl-6,7- dihydrothiazolo[3,2-a]pyrimidin-5-one derivatives

Author(s): Naema A. Mahmoud

Base catalyzed reaction of 2-acetyl-3,5-dimethyl-isothiazolo[2,3-a]pyrimidin-7-one (1) with malononitrile yielded the corresponding compound (2) which is cyclized with sulphur to give (3), also, compound (1) reacted with 2- cyanoacetohydrazide in acetic acid to give (4). On the other hand, by treatment of compound (1) with 2-amino-2- (hydroxy methyl) propane-1,3 diol gives (5) which reacted with phosphorous oxychloride to give (6).Finally, chalcone (7) is formed by the reaction of compound (1) with trimethoxy benzaldehyde (scheme.1). Compound (3) is reacted with ρ.nitrobenzaldehyde to give compound (8) which is reacted with thioglycolic acid in the presence of anhydrous Na2SO4 to give compound (9). Compound (3) is cyclized by ethylenediamine to give (10), also compound (3) reacted with chloroacetylchloride to give chloroderivative (11) which under heating with potassium thiocyanate yielded (12) (scheme 2). Compound (3) under heating with formic acid, formamide, malononitrile and ethylcyanoacetate yielded the compounds (13-16) respectively (scheme 3). Diazotization of the compound (3) with concentrated HCl and sodium nitrite at 0-5 °C yielded azodye derivative (17). On the other hand, Coupling of (3) with diazotized p.nitroaniline gave (18).Finally (3) is condensed with acetic anhydride and phthalic anhydride to give (19,20) respectively(Scheme 4).


PDF

FIND ARTICLES
SCImago Journal & Country Rank
 
Erkek öyle sert ve acımaz sikiyor ki bayan çaresiz bir şekilde tırtıl misali sikiş yataktan aşağı doğru kayıyor fakat hem adam hemde kadın aşırı mobil porno derecede zevk alıyorlar Uzun zamandır karısı ile ilgili planları olan türk porno adam onu başkaları sikerken hayal ediyor bu durumu karısından sikiş izle gizliyordu fakat bir gün adamın moralinin bozuk olduğunu anlayan karısı sikiş ona ne olduğunu sordu ve adamda ona her şeyi anlatmıştı karısı bu porno resim durumdan Büyük zenci yarağı sevenler için özel olarak eklenmiş videomuz türk porno kalın ve damarlı zenci siki arayıp bulamayanlar için özel olarak sikiş izle yayınlanmıştır filmde ise sarışın zengin sürtük büyük mobil sikiş kalın damarlı alet sevdiğini bir çok kez dile getirmiş