Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Synthesis and anti-cancer evaluation of cyclotriphosphazene hydrazone derivatives

Author(s): Basavaraj R. Patil, Shrinath S. Machakanur, Rekha S. Hunoora, Dayanand S. Badiger, Kalagouda B. Gudasi, and S. W. Annie Bligh

Hexasubstituted cyclotriphosphazene hydrazones [N3P3(-OC6H4-p-CH=N-NH-C(O)-C6H4-p-X)6] were prepared by the reaction of hexachlorocyclotriphosphazene with N'-(4- hydroxybenzylidene)-4-substituted-benzohydrazides [HO-C6H4-p-CH=N-NH-C(O)-C6H4-p-X]. The structures were confirmed by elemental analysis, FT-IR, 1H, 13C, 31P NMR and mass spectrometry. These cyclic model systems bearing hydrolysable hydrazone linkages were evaluated for their antiproliferative activity in vitro against the human liver carcinoma cell line (HepG2) and Human cervix carcinoma cell line (HeLa).


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