Synthesis and Anticancer Evaluation of Some New poly functionally
Substituted Pyrimidine-2-thione Derivatives

Rasha S. Gouhar; Usama Fathy; Mohamed F. El-Shehry; Salwa M. El-Hallouty

Abstract

Synthesis and Anticancer Evaluation of Some New poly functionally Substituted Pyrimidine-2-thione Derivatives

Author(s): Rasha S. Gouhar, Usama Fathy, Mohamed F. El-Shehry and Salwa M. El-Hallouty

The starting 5-cyano-6-(3,4-dimethoxyphenyl)-2-thiouracil 1 which prepared by reaction of ethyl cyanoacetate with thiourea and 3,4-dimethoxybenzaldehyde, was allowed to react with POCl3/PCl5 to give the key intermediate 4- chloropyrimidine-2-thione derivative (2). Compound 2 underwent several substitution reactions with sulfa drug, pamino acetophenone and benzocaine to give the corresponding substituted 4-amino derivatives 3, 4, 6, respectively. The hydrazides 5, α,β-unsaturated ketone 7 and its cyclized products 8, 9 were also prepared. The imidazopyrimidinthione 10, its Mannich bases and arylmethylene derivatives 11 and 12 were also prepared. Several other pyridoimidazopyrimidine-thiones and triazolopyrimidines were also synthesized. All newly prepared compounds were biologically evaluated for their anticancer activity against cancer cell lines.

PDF

Select your language of interest to view the total content in your interested language