Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Abstract

Synthesis and antifungal activity 2, 6-bis (subtituted phenyl)-1, 4-dihydro-3, 5- di (1H-imidazol-1-yl)-4-(subtituted phenyl) pyridine derivatives

Author(s): S. N. Mokale, Grover D. G, Maheshwari T. Shete

Novel series of 2, 6-bis (subtituted phenyl)-1, 4-dihydro-3, 5-di (1H-imidazol-1-yl)-4-(subtituted phenyl) pyridine antifungal agents having 1, 4- dihydropyridine ring and imidazole pharmacophore (4a-4p) were prepared successively by condensation of 1-(4-chlorophenyl)-2- (1H-imidazol-1-yl) ethanone with aromatic aldehyde and ammonium acetate. The chemical structures of the compound were confirmed by 1H NMR, IR and mass spectral data. The compounds were screened for antifungal activity against pathogenic fungal strains


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