Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Abstract

Synthesis and antifungal activity of some novel chalcones containing pyrazole moiety

Author(s): J. J. Vora, Dharmesh M. Patel, Ketan C. Parmar, Bhavesh M. Patel, Sunil. B. Vasava

Various chalcone derivatives of 1-(4-methyl sulfonylphenyl)-3-(1,3-diphenyl-1H-pyrazol-4-yl)-2-propen-1-one were
synthesized by condensation of 1,3-diphenyl-1H-pyrazole-4-carbaldehyde and 4-methyl sulfonylphenyl
acetophenone. Chalcone derivatives were characterized by FT-IR, 1H-NMR, Mass spectral analysis and elemental
analysis. All the synthesized compounds have been screened for their antifungal activities by using cup-plate
method.


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