Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Abstract

Synthesis and antifungal studies of bis-mono and difluorophenacyl azolium compounds

Author(s): Dhanraj T. S. S. Sundaram, Jayati Mitra, Aminul Islam, B. Venkateswara Rao, S.Paul Douglas

A new series of novel bis-mono and difluorophenacyl triazolium and imidazolium compounds were synthesized starting from mono and difluorophenacyl chloride, 1H-1,2,4-triazole and 1H-imidazole. Similarly, 4-amino mono and difluorophenacyl triazolium compounds were prepared from 4-amino-4H-1,2,4-triazole and mono and difluorophenacyl chloride. A comparative study of these compounds against the fungi (aspergillus niger, aspergillus flavus and penicillium chrysogenum) were screened, while keeping Amphotericin B as standard. The antifungal tests have shown that most of the synthesized azolium compounds exhibit slight to moderate activity against the selected fungi.


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