Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.


Synthesis and anti-HBV activity of 2-(methylthio)thieno[3,2-d]pyrimidin-4(1H)-one analogues of ACV

Author(s): Reem A. K. Al-Harbi and Adel A. H. Abdel-Rahman

Amino thiophenecarboxylates 1a-d were heated with thiourea to afford 2-thioxothieno[3,2-d]pyrimidin-4(1H)-ones 2a-d. 2-(Methylthio)thieno[3,2-d]pyrimidin-4(1H)-ones 3a-d were synthesized by alkylation of substituted 2-thioxo derivatives 2a-d with methyl iodide. Compounds 3a-d were treated with (2-acetoxyethoxy)methyl bromide to afford 4a-d which were deacetylated to afford 5a-d. The anti-HBV activity of selected compounds was studied.


SCImago Journal & Country Rank
Recommended Conferences
bornova escort karşıyaka escort osmangazi escort buca escort anne porno fetiş porno anal porno bartın escort burdur escort eskişehir escort escort izmir bursa escort porno escort bayan