Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Synthesis and anti-inflammatory activity of some novel 1,2-pyrazoline derivatives

Author(s): Nitin S. Gonjare, Suhas S. Awati, Sachin R. Kumbhoje, Pramod B. Patil, Shitalkumar S. Patil and Manish S. Kondawar

Pyrazolines are well known, and important nitrogen containing five-membered heterocyclic compounds. It has been reported to show a broad spectrum of biological activities including antibacterial, antifungal, anti-inflammatory, and antidepressant activities and Its derivatives, possess a wide range of biological and physiological activities such as antitumor, antiarthritic, analgesic, immunosuppressive activities. In view of this various pyrazoline derivatives were synthesized and assessed for the anti-inflammatory activity. In this article new substituted several 1,2 Pyrazoline derivatives were synthesized by reacting Chalcones with hydrazine hydrate in dry benzene. The structures of the synthesized compounds were confirmed by spectral data. Compounds have been screened for antiinflammatory activity by using Carrageenan induced rat hind paw oedema. Among the 7 compounds that were screened for anti-inflammatory activity, compounds SP1 to SP4 showed 30%, 34%, 30% and 32% inhibition of oedema volume, while the standard drug (Ibuprofen) showed inhibition of 51%.


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