GET THE APP

Synthesis and Antimicrobial Activities of some Novel Pyridines Carrying Pyrazolobenzothieno[2,3-d]pyrimidine Unit | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.

Abstract

Synthesis and Antimicrobial Activities of some Novel Pyridines Carrying Pyrazolobenzothieno[2,3-d]pyrimidine Unit

Author(s): Mohamed Abdel-Megid, Azza M El-Kazak, Kamelia M EL-mahdy, Magdy Seada, Osama Farouk

1,6-Diamino-2-oxo-4-[(10-oxo-4,6,7,8,9,10-hexahydropyrazolo[1,5-a][1]benzothieno[2,3-d]pyrimidin-3-yl)-1,2-dihydropyridine-3,5-dicarbonitrile (2) reacted with some mono electrophilic reagents such as acetic anhydride, carbon disulfide, chromone-3-carboxylic acid and anthranilic acid to give a novel series of triazolo[1,5-a] pyridines 3-6. Cyclocondensation of compound 6 with carbon disulphide and acetic anhydride afforded pyrido[1,2:2,3]triazolo[1,5-c]quinazolines 7,8. Also, the new pyrido[1,2-b][1,2,4]triazines 9-14 were yielded from interaction of, respectively. The effect of some α,γ-bifunctional electrophiles such as 2 compound 2 reacted with chloroacetyl chloride, oxalyl chloride, sodium pyruvate and/or benzyl -cyano-3,3-bis(methylthio)acrylonitrile, 2-cyano-3,3-bis(methylthio) prop-2-enamide,5-chloro-3-methyl-1-phenylpyrazole-4-carboxaldehyde, chromone-3-carbo-nitrile, 4-chlorobenzylidene malononitrile and/or ethyl 3-(4-chlorophenyl)-2-cyanoprop-2-enoate on compound 2 was also studied and gave some new pyrido[1,2-b][1,2,4]triazipines 15-21. The synthesized compounds were showed a low to high antimicrobial activity towards Gram- positive bacteria, Gram-negative bacteria, yeasts and the fungal strain.


PDF

Select your language of interest to view the total content in your interested language

30+ Million Readerbase
SCImago Journal & Country Rank
Google Scholar citation report
Citations : 23677

Der Pharma Chemica received 23677 citations as per Google Scholar report

Der Pharma Chemica peer review process verified at publons
Der Pharma Chemica- Journals on pharmaceutical chemistry