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Synthesis and antimicrobial activity of 2-[1-phenyl-3-arylpyrazol-4-yl]benzothiazolines | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
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Abstract

Synthesis and antimicrobial activity of 2-[1-phenyl-3-arylpyrazol-4-yl]benzothiazolines

Author(s): Meenakshi1*, Parvin Kumar2, Sunil Kumar3

A convenient and solventless synthesis of 2-[1-phenyl-3-arylpyrazol-4-yl]benzothiazolines is reported. The procedure does not involve the use of any additional reagent/catalyst, produces no waste, and represents a green synthetic protocol. The structures of newly synthesized compounds were confirmed by IR, 1H NMR, 13C NMR, mass and elemental analyses. All the seven compounds were evaluated for in vitro antibacterial activity against Gram-positive Bacillus subtilis, Staphylococcus aureus, Gram-negative Escherichia coli and in vitro antifungal activity against Candida albicans and Aspergillus niger.


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