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Synthesis and Antimicrobial Activity of 2-(4-((4-substituted phenoxy)methyl)-1H-1,2,3-triazol-1-yl)-N-arylacetamides | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

Synthesis and Antimicrobial Activity of 2-(4-((4-substituted phenoxy)methyl)-1H-1,2,3-triazol-1-yl)-N-arylacetamides

Author(s): Kaushik CP, Krishan Kumar

2-(4-((4-substituted phenoxy)methyl)-1H-1,2,3-triazol-1-yl)-N-arylacetamides (7a-7j) were synthesized through copper(I)-catalyzed click reaction of 1-methyl-4-(prop-2-ynyloxy)benzene (3a) and 1-nitro-4-(prop-2-ynyloxy)benzene (3b) with 2-azido-N-arylacetamides. The structural confirmation of the synthesized compounds was carried out by using various spectral techniques (FT-IR, 1H-NMR, 13C-NMR, HRMS). The synthesized compounds which reflects in general the various 1,4-disubstituted 1,2,3-triazoles were screened for in vitro antibacterial activity against Escherichia coli, Pseudomonas aeruginosa (Gram negative bacteria), Bacillus subtilis, Staphylococcus aureus (Gram positive bacteria) and antifungal activity against Candida albicans, Aspergillus niger. Compound 7i displayed good antimicrobial activity against tested bacterial and fungal strains.

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