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Synthesis and antimicrobial activity of 3-cyanamidino-5-glycosylimino-1,2,4-thiadiazolines | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Abstract

Synthesis and antimicrobial activity of 3-cyanamidino-5-glycosylimino-1,2,4-thiadiazolines

Author(s): Madhuri B. Saoji and Shirish P. Deshmukh

The synthesis of novel glycosides derivatives and investigation of their chemical and biological behavior have gained more importance in recent decades. 3-cyanamidino-5-glycosylimino-1,2,4-thiadiazolines were synthesized by the oxidative cyclization of glycosyl-3-cyanamidino thiocarbamides. The 1-glycosyl-3-cyanamidino thiocarbamides were prepared by the interaction of glycosyl isothiocynates with dicyanodiamide. The identities of these newly synthesized compounds have been established on the basis of usual chemical transformations and IR, 1H NMR and Mass spectral studies. The synthesized compounds were assayed for their antimicrobial activity most of them possess moderate to significant activity.


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