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Synthesis and Anti-microbial activity of a new class of ├?┬▒-Aminophosphonic acid esters by using TMG as Catalyst | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Abstract

Synthesis and Anti-microbial activity of a new class of ├?┬▒-Aminophosphonic acid esters by using TMG as Catalyst

Author(s): G. Chandra Sekhar Reddy, S. Annar, K. Uma Maheshwara Rao, A. Balakrishna, C. Suresh Reddy

A new class of α-aminophoshonic acid esters (3a-j) has been synthesized by equimolar quantities of Schiff’s bases, diethyl/dimethyl hydrogen phosphites in dry ethanol at refluxing conditions using TMG as a catalyst via Pudovik reaction in high yields (71-87%). The structures of the title compounds have been established by elemental analysis, IR, 1H-, 13C- & 31P- NMR and Mass spectral analysis. They were found to possess significant anti-microbial activity.


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