Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Abstract

Synthesis and antimicrobial activity of novel 1-thiocarbamoyl-2-pyrazoline derivatives

Author(s): N. Rama Rao, M. V. Basaveswara Rao and K. Lakshmi

To the continuation of our research work in the present study, eighteen novel quinazolinonyl-1- thiocarbamoyl-2- pyrazolines (3a-r) were synthesized from the cyclization of different thioxoquinazolinonyl chalcones with thiosemicarbazide. The structures of the newly synthesized compounds were confirmed by IR, 1H NMR and Mass spectroscopic analysis and all were tested for their antimicrobial potential. Most of the synthesized compounds showed significant antimicrobial activities when compared to control and standard drugs.


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