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Synthesis and anti-microbial activity of novel series of Substituted 2- (Tetrazolo[1,5- a]quinoxalin-4-yl)-2,3-dihydrophthalazine-1,4-dione derivatives | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

Synthesis and anti-microbial activity of novel series of Substituted 2- (Tetrazolo[1,5- a]quinoxalin-4-yl)-2,3-dihydrophthalazine-1,4-dione derivatives

Author(s): B. Srinivas, B. Prasanna and M. Ravinder

A novel and efficient synthesis of substituted 2-(Tetrazolo[1,5-a]quinoxalin-4-yl)-2,3-dihydrophthalazine-1,4- dione has been carried out. The substituted 4-hydrazinyl tetrazolo quinoxalines has been treated with pthalic anhydride. The structures of all the compounds were confirmed by IR, 1H-NMR, elemental analysis and Mass spectroscopy. All the synthesized compounds 5(a-g) were screened for anti-microbial activity. Among all the synthesized compounds 5a, 5c, and 5d and 5e, 5f and 5g showed moderate activity against gram-positive bacterial strains S. aureus and gram-negative bacterial strains E.coli. 5e showed appreciable activity against C. albicans and A. niger organism.


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