Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.


Synthesis and Antimicrobial Activity of Schiff’s and Mannich Bases of 1H-Indole-2,3-Dione Derivatives

Author(s): Umesh K. Singh, Surendra N. Pandeya, Sunil Jindal, Manoj Pandey, Birendra K. Srivastava, Anamika Singh

1H-indole-2,3-dione and its derivatives were reacted with 4-amino-N-(5,6- dimethoxypyrimidin-4-yl)benzenesulfonamide to form Schiff’s bases and the Mannich bases of these compounds were synthesized by reacting them with formaldehyde and piperidine. All the compounds were characterized by means of their IR, 1H NMR spectroscopic data and elemental analysis. The antimicrobial activity of these compounds was evaluated by tube dilution method. All compounds showed considerable enhanced antibacterial activity (low MIC) against all bacteria when compared to reference drug sulfadoxine. None of the compounds was active against C. abony. None of the compounds showed antifungal activity.


SCImago Journal & Country Rank
Recommended Conferences
bornova escort karşıyaka escort osmangazi escort buca escort anne porno fetiş porno anal porno bartın escort burdur escort eskişehir escort escort izmir bursa escort porno escort bayan