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Synthesis and antimicrobial activity of several substituted pyridin-1-yl-4H-1,2,4-triazole-3-thioles | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

Synthesis and antimicrobial activity of several substituted pyridin-1-yl-4H-1,2,4-triazole-3-thioles

Author(s): Ranjana Dubey, Tilak Ram and Nidhi Chaudhary

Several 5-substitutedphenyl-4-[6-{2-(1-(3-(thiophen-2-yl)phenyl)ethylidene)hydrazinyl}1H-pyrrolo[2,3-b] pyridin- 1-yl]4H-1,2,4-triazole-3-thioles 4a-f have been synthesised and screened for antibacterial and antifungal activities. Structures of the synthesized derivatives were characterized by IR, 1H-NMR, Mass and elemental analysis (C, H, N). Compound 4f displayed significant antimicrobial activity.


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