Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Abstract

Synthesis and antimicrobial activity of some new 3, 4-disubstituted pyrroles and pyrazoles

Author(s): Syamaiah K. 1 , Durgamma S. 1 , Sudheer K. 2 , Padmavathi V. 1 and Padmaja A. 1 *

Some new 3,4-disubstituted pyrroles and pyrazoles w ere prepared from the synthetic intermediate (E)-1- (4-(m- chlorobenzyloxy)-3-methoxyphenyl)-3-(4-aryl)prop-2- en-1-one on treatment with tosylmethyl isocyanide a nd diazomethane. All the target compounds were evaluat ed for antimicrobial activity. The chloro substitut ed pyrroles and pyrazoles ( 5c , 7c ) exhibited pronounced antimicrobial activity parti cularly against S. aureus and P. chrysogenum


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