Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Abstract

Synthesis and antimicrobial activity of some new isatins derivatives

Author(s): Bhavesh R Nathani, Kishor S Pandya, Manish M Jeni, Mayur R Patel

Some new N-[3-(2-Oxo-1, 2-dihydro-indol-3-ylidene-hydrazinocarbonyl)-benzyl]-nicotinamide (III) have been synthesised from different isatin derivatives (I) by condensing with N-(3- hydrazinocarbonylbenzyl) nicotinamide (II). Their chemical structures have been confirmed by IR, 1H NMR, Mass and by elemental analysis. Investigation of antimicrobial activity of compounds was done by the disk diffusion technique. Among the compounds tested, the compound with 5-F, 5-CH3 substitution showed the most favourable antimicrobial activity.


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