In present research work, phthalimide is esterified with chloro ethylacetate followed by amination using hydrazine hydrate. Thus formed phthalimido acetohydrazide (2) was condensed with various substituted aldehydes to yield Arylidene phthalimido acetohydazides (Schiff bases) (3a-3j) which on cycloaddition with thioglycollic acid yield arylidene 4-oxo-1,3-thiazolidine phthalimido acetohydrazides (4a-4j). Structures of all the synthesized compounds were identified and characterized by melting point determination, TLC, FT-IR, 1H NMR and Mass spectral analysis. Compounds (3a-3j) & (4a-4j) were screened for their antimicrobial activity viz., antibacterial and antifungal activity using Ciprofloxacin and Ampicillin as standard drugs for antibacterial activity; Fluconazole and Amphotericin B as standard for antifungal activity.
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