Synthesis and Antimicrobial Evaluation of Novel Hydrazones and 1,3,4-Oxadiazoles Incorporating Bumetanide Derivatives

Mustafa I; Mostafa SM; El-Sabbagh OI; Ibrahim TS; Abdulrahman A; Bendary MM

Abstract

Synthesis and Antimicrobial Evaluation of Novel Hydrazones and 1,3,4-Oxadiazoles Incorporating Bumetanide Derivatives

Author(s): Mustafa I, Mostafa SM, El-Sabbagh OI, Ibrahim TS, Abdulrahman A, Bendary MM

The aim of this study is to synthesize new benzenesulfonamide derivatives that possess antibacterial activity using Bumetanide as a precursor of benzenesulfonamide. A novel series of hydrazones containing benzenesulfonamides (4_a-i) and 1,3,4 oxadiazole containing benzenesulfonamides (5_a-e) were prepared and their antibacterial and antifungal activities were measured using microplate broth assay against Gram-positive: Staphylococcus aureus, Gram-negative: Escherichia coli and Pseudomonas aeruginosa and Fungi: Aspergillus fumigates and Candida albicans. The results showed that some of the prepared compounds exhibit a good to excellent activity against the mentioned bacteria, however all the series showed no activity against fungi. Among the series, Compound (4_i) demoed an excellent antibacterial activity better than that of the standard reference (Sulfamethoxazole) against Escherichia coli, while compounds (4_c, 4_e, 4_g) showed good activity against all tested bacterial strains equals to Sulfamethoxazole activity. Moreover, compounds (4_g, 5_d) exert an antimicrobial activity equals to that of Sulfamethoxazole against P. aeruginosa, while compounds (4_a, 4_b, 4_c, 4_f, 4_g, 4_h) exhibit similar activity to Sulfamethoxazole against Escherichia coli.