The purpose of study was to synthesize the focused library of new malononitrile derivative of substituted Nphenylpyrrolidine- 2, 5-dione as potential new hybrid antifungal molecules. These hybrid molecules were synthesized in a coupling reaction of substituted N-phenylpyrrolidine-2, 5-dione with dicyanomethane using solvent free ecofriendly microwave assisted method. The 2, 5-diones were prepared by the reaction of succinic anhydride with substituted aryl amines in presence of benzene and acetyl chloride. All the synthesized molecules were persisted and vetted for antimicrobial activities. Most of the molecules showed potential antifungal activity against Candida albicansandAspergillusniger.