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Synthesis and antimicrobial screening of 2-mercaptobenzimidazole derivatives | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

Synthesis and antimicrobial screening of 2-mercaptobenzimidazole derivatives

Author(s): Kiran M. Kulkarni*, Sagar A. Jadhav, Pramod B. Patil, Vikas R. Dhole and Shitalkumar S. Patil

The new series of 2-mercaptobenzimodazole derivative were synthesized by using secondary amine i.e. diethyl amine and aromatic aldehyde. In Mannish reaction instead of formaldehyde other aromatic aldehyde was used. That was main aim of present study. The purity of synthesized compounds was checked by Melting point and TLC and their structure was established by various analytical techniques such as IR,1HNMR, Mass spectral studies.Thsese Compounds were screened for their Antimicrobial, Anticonvulsant activity. Antibacterial activity was screened by using Paper disc method. Anticonvulsant activity was evaluated by PTZ induced model.


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