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Synthesis and antimicrobial studies of new thiadiazoline based symmetrical bisheterocyclics | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

Synthesis and antimicrobial studies of new thiadiazoline based symmetrical bisheterocyclics

Author(s): Mohamad Yusuf and Payal Jain

The bisheterocyclic compounds 4a-4h have been prepared in good yields from the cyclization of bisthiosemicarbazones 3a-3h with acetic anhydride. The condensation reaction of bisacetophenones 2a-2h with thiosemicarbazide in alcoholic medium provided 3a-3h and the former were obtained from the O-alkylation of 4- hydroxyacetophenone with suitable 1,ω-dibromoalkanes under alkaline conditions in the presence of dry EtOH/DMF. The intermediates 3a-3h and bisthiadiazolines 4a-4h were also screened for their in vitro antimicrobial activities. Most of the compounds showed significant activity against the tested microorganisms.


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