GET THE APP

Synthesis and antimicrobial studies of new thiadiazoline based symmetrical bisheterocyclics | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.

Abstract

Synthesis and antimicrobial studies of new thiadiazoline based symmetrical bisheterocyclics

Author(s): Mohamad Yusuf and Payal Jain

The bisheterocyclic compounds 4a-4h have been prepared in good yields from the cyclization of bisthiosemicarbazones 3a-3h with acetic anhydride. The condensation reaction of bisacetophenones 2a-2h with thiosemicarbazide in alcoholic medium provided 3a-3h and the former were obtained from the O-alkylation of 4- hydroxyacetophenone with suitable 1,ω-dibromoalkanes under alkaline conditions in the presence of dry EtOH/DMF. The intermediates 3a-3h and bisthiadiazolines 4a-4h were also screened for their in vitro antimicrobial activities. Most of the compounds showed significant activity against the tested microorganisms.


PDF

Select your language of interest to view the total content in your interested language

30+ Million Readerbase
SCImago Journal & Country Rank
Google Scholar citation report
Citations : 15261

Der Pharma Chemica received 15261 citations as per Google Scholar report

Der Pharma Chemica peer review process verified at publons
Der Pharma Chemica- Journals on pharmaceutical chemistry