Synthesis and antimicrobial studies of some thiazolo [2, 3-b]benzo[f]quinazoline and thiazino[2,3-b]benzo[f]quinazoline derivatives

Ram Pal Chaudhary

Abstract

Synthesis and antimicrobial studies of some thiazolo [2, 3-b]benzo[f]quinazoline and thiazino[2,3-b]benzo[f]quinazoline derivatives

Author(s): Ram Pal Chaudhary

3, 4-dihydronaphthalen-2(1H)-one on condensation with p-tolualdehyde gives 1-benzylidene derivative which on reaction with thiourea yields 1-p-tolyl-1,2,5,6- tetrahydrobenzo[f]quinazoline-3(4H)-thione (2). The thione 2 on reaction with chloroacetic acid and 3-chloropropionic acid furnishes compounds 3, 4 and not their other possible isomers, 6 and 7 respectively. The cyclised product 3 on reaction with aromatic aldehydes produces arylidene thiazolidinones, 5 which can also be obtained directly from 2. Compounds 3 and 4 represent a novel heterocyclic system. The structural assignments of 3, 4 and 5 are based on elemental analysis, 1H NMR, IR and mass spectral data. The compounds (3-5) were screened for antimicrobial activity and showed promising inhibition of S.aureus, C.diphtheriae, P.aeruginosa and E. coli bacteria.

PDF

Select your language of interest to view the total content in your interested language