Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry


Synthesis and anti-mycobacterium study of some fluorine containing schiff bases of quinoline and their metal complexes

Author(s): Mustapha C. Mandewale, Bapu R. Thorat and Ramesh S. Yamgar

Five new quinoline Schiff bases were synthesized starting from 6-fluoro-2-hydroxyquinoline-3-carbaldehyde. In the reaction sequence, Fluorine substituted anilines were condensed to 6-fluoro-2-hydroxyquinoline-3-carbaldehyde. Further Zn (II) and Cu (II) complexes of Schiff bases were synthesized. Structure of synthesized compounds has been confirmed by employing various spectroscopic techniques like H1NMR, FTIR and Mass Spectroscopy. The newly synthesized Schiff bases and their Zn (II) and Cu (II) complexes were evaluated for their anti tuberculosis activity against Mycobacterium tuberculosis. Initial results indicated that most of the Schiff base derivatives and their metal complexes demonstrated very good anti tuberculosis activities. The most effective compounds SB01 to SB05 series and C01-C05 series have exhibited an MIC value in the range of 1.6 to 3.2 μg/ml against M. tuberculosis H37Rv strain that is comparable to first line anti-tuberculosis drug. Fluorescent properties of synthesized Schiff bases as well as metal complexes were studied.