Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry


Synthesis and antioxidant activities of naturally occurring alpinum isoflavone, 4′-O-methylalpinum isoflavone and their synthetic analogues

Author(s): Salah Hamza Sherif, Siddaiah Vidavalur, P. Muralidhar and Y. L. N. Murthy

Naturally occurring isoflavone viz, alpinum isoflavone, 4′-O-methylalpinum isoflavone, and a series of five analogues were synthesized by prenylation of isoflavone (4) which was synthesized from phloroglucinol. The structures of all the synthesized compounds were confirmed using 1HNMR, 13CNMR spectral data and mass spectroscopy. Antioxidant activities of the above compounds were investigated. The synthesized compounds exhibited less significant activity compared to vitamine C.