The present study envisaged the discovery of novel antioxidant candidates using the indole incorporated morpholine scaffold. The structures of the final compounds were ascertained by IR, 1HNMR, 13CNMR and Mass analyses. All the final compounds screened in vitro antioxidant activity by DPPH method with ascorbic acid as positive control. Among the final derivatives,2-methyl-1-(2-morpholinoethyl)-1H-indole-3-carboxylicacid-3,4dimethoxyaniline (IVb) showed good antioxidant activity with an IC50 of 57.46μg/ml. It has been concluded that the presence of dimethoxyl group in the adjacent position in the aromatic region of the titled derivatives can contribute significant antioxidant activity.