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Synthesis and antioxidant, antimicrobial activity o f 6-cyano-5-imino-2-methyl- 7-(methylthio)-5H-thiazolo [3, 2- a ] pyrimidines | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

Synthesis and antioxidant, antimicrobial activity o f 6-cyano-5-imino-2-methyl- 7-(methylthio)-5H-thiazolo [3, 2- a ] pyrimidines

Author(s): Avinash V. Pawde, Datta S. Kawale, and Sambhaji P. Vartale*

New heterocyclic compound 6-cyano-5-imino-2-methyl- 7-(methylthio)-5H-thiazolo [3, 2-a] pyrimidines (3) reported by reacting of 2-amino-5-methyl thiazole (1) with bis(methylthio) methylene malanonitrile (2) . Further the compound (3) was treated with aryl amines, substituted phenols, active methylene compounds and heteryl amines to obtain its 7-substituted derivatives. Newly synthes ized thiazolo [3, 2-a] pyrimidines derivatives were screened for their antimicrobial and antioxidant activity.


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