Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Synthesis and Antioxidant Properties of Some [2-Methoxy-5-(3-alkyl-4,5- dihydro-1H-1,2,4-triazol-5-one-4-yl)-azomethinphenyl benzoates

Author(s): Şule Bahçeci, Nuri Yıldırım, Özlem Gürsoy-Kol, Murat Beytur and Haydar Yüksek

In this paper, ten novel [2-Methoxy-5-(3-alkyl-4,5-dihydro-1H-1,2,4-triazol-5-one-4-yl)-azomethinphenyl benzoates (4) were obtained with the reactions of 3-alkyl(aryl)-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones (2) and 3- benzoxy-4-methoxbenzaldehyde (3), which has been synthesized by the reaction of 3-hydroxy-4- methoxybenzaldehyde with benzoyl chloride by using triethylamine. The novel synthesized compounds were identified by IR, 1H NMR, 13C NMR and UV spectral data. Besides, the newly synthesized compounds were analysed for their in vitro potential antioxidant capacities in three different techniques. Compounds 4e, 4g and 4i demonstrated significant activity for metal chelating effect.


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