Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.
Abstract
Synthesis and antitumor activity of novel pyrazolo[3,4-d]pyrimidines and related heterocycles
Author(s): Manal M. Kandeel , Sameha M. Ali, Eman K. A. Abed ElALL, Mohamed A. Abdelgawad , and Phoebe F. LamieThe reaction between 5-amino-4-imino-3-methyl-1-phenyl-1,4-dihydro-pyrazolo[3,4-d]pyrimidine (2a) or (3- methyl-1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)- hydrazine (3) and several available reactants afforded new heterocycles with pyrazolo[3,4-d]pyrimidine nucleus. Some of the newly synthesized compounds were screened against MCF-7 cell line, compounds 4b, 5a, 10c and 12c showed the highest activity among the tested compounds with IC50 between 0.013 and 0.018 μM.
Select your language of interest to view the total content in your interested language
Google Scholar citation report
Citations : 25868
Der Pharma Chemica received 25868 citations as per Google Scholar report
Der Pharma Chemica peer review process verified at publons
DOWNLOADS
