GET THE APP

Synthesis and antitumor activity of some new 1,3,4-oxadiazole, pyrazole and pyrazolo[3,4-d]pyrimidine derivatives attached to 4-benzothiazol-2-yl phenyl moiety | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.

Abstract

Synthesis and antitumor activity of some new 1,3,4-oxadiazole, pyrazole and pyrazolo[3,4-d]pyrimidine derivatives attached to 4-benzothiazol-2-yl phenyl moiety

Author(s): Wageeh S. El-Hamouly, Kamelia M. Amin, Samy A. El-Assaly and Eman A. Abd El-Meguid

Some 1,3,4-oxadiazole, pyrazole and pyrazolo[3,4-d]pyrimidine derivatives were synthesized starting from o-aminothiophenol 1 by reacting with different electrophilic and nucleophilic reagents. Some of the newly synthesized compounds have been evaluated for their potential cytotoxicity against breast cancer cell line (MCF7), compound 6c exhibited the highest activity.


PDF

Select your language of interest to view the total content in your interested language

30+ Million Readerbase
SCImago Journal & Country Rank