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Synthesis and antiviral activity of novel 3,5-disubstituted-1,2,4-triazole glycoside derivatives | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
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Abstract

Synthesis and antiviral activity of novel 3,5-disubstituted-1,2,4-triazole glycoside derivatives

Author(s): Ashraf M. Mohamed, Wael A. El-Sayed, Naglaa A. Abdel-Hafez and Ola Bagato

New 1,2,4-triazoles linked to different condensed azole and quinolin-8-yloxymethyl moieties were synthesized. Glycosylation of the produced 1,2,4-triazoles followed by deacetylation afforded the free hydroxyl N-glycosides. The antiviral activity against H5N1 avian influenza virus strain A/Egypt/M7217B/2013 was reported and a number of compounds showed moderate activity.


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