Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
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Abstract
Synthesis and bio-activity evaluation of carbamate and sulfonamide derivatives of febuxostat
Author(s): P. Vedavathi and C. Naga Raju*Febuxostat was modified as their carbamates and sulfonamides by the reaction of Febuxostat with hydrazine followed by various Chloroformates/sulfonylchlorides in the presence of triethylamine at 40-45oC in THF. The newly synthesized compounds were characterized by IR, NMR (1H &13C), LCMS and C, H, N elemental analysis. Antimicrobial screening of all the title compounds demonstrating the compounds exhibited good activity.
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Citations : 25868
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