Synthesis and bioactivity evaluation of novel bipyenyl thioxo pyrimidines as potent antimicrobial agent | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
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Synthesis and bioactivity evaluation of novel bipyenyl thioxo pyrimidines as potent antimicrobial agent

Author(s): Pineshkumar N. Patel* 1 and Denish C. Karia 2

Thioxo Pyrimidine and Biphenyl moieties are well kn own for their valuable medicinal properties. The pr esent research work describes the synthesis of novel Biph enyl Thioxo Pyrimidine derivatives and evaluation o f their medicinal value . The reaction of 4'-Bromomethyl-biphenyl-2-carbonitr ile with 4’-Hydroxy acetophenone in presence of Sodium carbonate produced 4'-(4-Acetyl- phenoxymethyl)-biphenyl-2-carbonitrile (IN-1). The reaction of IN-1 with substituted aromatic aldehyde and Sodium hydro xide afforded various substituted Chalcones; 4'-{4- [3- (2-Chloro-phenyl)-acryloyl]-phenoxymethyl}-biphenyl -2-carbonitrile (IN-2) . Finally, the reaction of IN-2 with Thiourea in presence of Sodium hydroxide produced 4 '-{4-[6-(2-Chloro-phenyl)-2-thioxo-2,3-dihydro-pyri midin-4- yl]-phenoxymethyl}-biphenyl-2-carbonitrile (CB, A-O) . The chemical structures of synthesized compounds we re characterized by 1 H-NMR, 13 C-NMR and FT-IR. Synthesized compounds were screene d for their antimicrobial activity. The compound CB-G was found to be the mos t potent antibacterial agent among all synthesized compounds .


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