Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Abstract

Synthesis and biological activities of some novel substituted quinazoline derivatives

Author(s): K. Vijayakumar and A. Jafar Ahamed

A simple method for the synthesis of title compounds is reported, which were isolated from a series of reactions. After nucleophilic reaction of 2-phenyl-3, 1benzoxazin-4(3H)-one with thiosemicarbazide and hydrazinehydrate to furnish quinazolinylthiourea, followed by aromatic acidchloride, all the compounds synthesized were screened for their potential anticancer, antidiabetic, anti tumor and anti asthmatic properties, which exhibited some authentic results towards testing organism in vitro and in vivo studies.


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