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Synthesis and biological activity of 4-bromo-2-hydroxy-N-(5- methylene-4-oxo-2-aryl-thiazolidin-3-yl) benzamide | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

Synthesis and biological activity of 4-bromo-2-hydroxy-N-(5- methylene-4-oxo-2-aryl-thiazolidin-3-yl) benzamide

Author(s): Sonal Maheta

4-bromo-2-hydroxy benzoic acid hydrazide (1) undergoes facile condensation with aromatic aldehydes to afford the corresponding 4-bromo-2-hydroxy benzoic acid arylidene hydrazides (2a-h) in good yields. Cyclocondensation of compounds (2a-h) with thioglycolic acid yields 4-bromo-2-hydroxy- N (4-oxo-2-aryl- thiazolidin -3-yl) benzamides (3a-h). These (3a-h) compounds are for the reacted with benzaldehyde in the presence of sodium ethanolate affords, giving 4-bromo-2-hydroxy- N (5-methylene-4-oxo-2-aryl- thiazolidin -3- yl)benzamides (4a-h). The structures of these compounds were established on the basis of analytical and spectral data. All the newly synthesized compounds were evaluated for their antibacterial and antifungal activities.


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