Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Abstract

Synthesis and biological activity of N-[-3-{-(4-substitutedaryl-3- chloro-2-oxo-azetidine)-carbamyl}propyl]-2-aminothiazole by conventional and microwave irradiation

Author(s): Pushkal Samadhiya, Ritu Sharma, S.K. Srivastava and S.D. Srivastava

A new series of N-[3-{-(4-subtitutedaryl-3-chloro-2-oxo-azetidine)-carbamyl}-propyl]-2- aminothiazole 4(a-s) have been synthesized from 2-aminothiazole as a starting material by conventional as well as microwave methods. All the synthesized compound 4(a-s) were screened for their antibacterial and antifungal activities against some selected bacteria and fungi with their MIC values and antitubercular activity screened against M. tuberculosis. The structure of all the synthesized compounds were confirmed by chemical and spectral analyses such as IR, 1H NMR, 13C NMR and FAB-Mass.


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