Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
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Abstract
Synthesis and biological activity of novel phthalamide containing azitidinone
Author(s): Gunvantsinh T. Desai, F. B. Bux and Arun Singh4-(1,3-dioxoisoindolin-2-yl)benzohydrazide (1) undergoes facile condensation with aromatic aldehydes to afford the corresponding N'-arylidene-4-(1,3-dioxoisoindolin-2-yl)benzohydrazide (2a-e) in good yields. Cyclocondensation of compounds (2a-e) with chloro acetyl chloride yields N-(3-chloro-2-oxo-4- arylazetidin-1-yl)-4-(1,3-dioxoisoindolin-2-yl)benzamide (3a-e). The structures of these compounds were established on the basis of analytical and spectral data. The newly synthesized compounds were evaluated for their antibacterial and antifungal activities.
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