A novel series of N-(1-methylpiperidin-4-yl)-2-(arylsulfonyl)-1H-indol-4-yl-amines was designed and synthesized as potential 5-HT6 receptor ligands and tested for human 5-HT6 receptor binding affinities. All the tested compounds showed moderate to high binding affinities towards 5-HT6 receptor. The most potent compound 11b was selected as a hit which can be further optimized to get the potential 5-HT6 receptor ligands.
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