Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
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Abstract
Synthesis and biological activity of novel substituted N-(1-methylpiperidin-4yl)-2-(arylsulfonyl)-1H-indol-4-yl-amines as 5-HT6 receptor ligands
Author(s): Jagadish Babu Konda, Ramakrishna V. S. Nirogi, Anil K. Shinde,Kiran Kumar Kandukuri, K. R. Sastry and P. K. DubeyA novel series of N-(1-methylpiperidin-4-yl)-2-(arylsulfonyl)-1H-indol-4-yl-amines was designed and synthesized as potential 5-HT6 receptor ligands and tested for human 5-HT6 receptor binding affinities. All the tested compounds showed moderate to high binding affinities towards 5-HT6 receptor. The most potent compound 11b was selected as a hit which can be further optimized to get the potential 5-HT6 receptor ligands.
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Citations : 25868
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