Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Abstract

Synthesis and Biological Activity Studies of Novel Arylazo Pyrazole Derivatives

Author(s): Revanasiddappa BC, Jose N

A series of novel 3,5-dimethyl arylazo pyrazoles (3a-i) were synthesized by reacting various oxybutyrates with methyl paraben (1) in glacial acetic acid medium. The key intermediate oxybutyrates (2a-i) were prepared from substituted phenyl diazonium salts and acetyl acetone in alcohol medium. The structures of the synthesized compounds have been established on the basis of spectral data (IR, 1H-NMR, Mass). The antibacterial and antifungal activity of the compounds has also been evaluated. Few of them have shown significant antifungal activity when compared to standard Flucanazole.


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