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The title compounds were synthesized by refluxing different substituted chalcones (4a-j) with 2-(3-chloro-4-methyl- 2-oxo-2H-chromen-7-yloxy)acetohydrazide (3) in presence of glacial acetic acid. Compound (3) was prepared by the reaction of 3-chloro-7-hydroxy-4-methyl-2H-chromen-2-one (1) with ethyl chloroacetate and subsequent treatment with hydrazine hydrate. The newly synthesized compounds were characterized by 1H NMR, IR, and Mass spectral data. Further all the compounds were screened for antimicrobial activity.