Pyrazoles are heterocyclic compounds with five member ring, with two nitrogen atoms in adjacent position. They shows excellent biological activities such as antimicrobial, anti-inflammatory, anticancer, analgesic, anticonvulsant, anthelmintic, antioxidant and herbicidal. So it was thought to synthesized these compounds and study their antimicrobial and antifungal activities. 4-Chloro-2-(1-substituted-5-aryl-pyrazolin-3-yl)-naphthalen-1- ols were suspended in DMSO in 250 ml R.B.flask fitted with condenser and then crystal of Iodine was added to it. The reaction mixture was stirred and refluxed for 1 hour 30 Min. The contents were cooled and diluted with water . The product obtained was filtered and washed with 10% aqueous sodium thiosulphate and crystallized from ethanol acetic acid mixture to obtained 3-(4-chloro-1-hydroxynaphthalen-2-yl)-5-aryl-1-substituted-pyrazoles. The synthesized compounds were characterized by elemental analysis, 1H NMR, IR Spectroscopy. All Newly synthesized compound were scanned for their biological activities specially antimicrobial and antifungal activities and all newly synthesized compounds shows an excellent antimicrobial and antifungal activities.
Select your language of interest to view the total content in your interested language