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Synthesis and biological evaluation of 3-methyl- 2-pyrazolin-5-one derivatives containing thiazole and indole moieties | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

Synthesis and biological evaluation of 3-methyl- 2-pyrazolin-5-one derivatives containing thiazole and indole moieties

Author(s): Mohamed S. Mostafa and Nasser M. Abd El-Salam

In the present work six 3-methyl-1-[(5-substituted-1H-indol-2-yl) carbonyl]-4-{[4- (substituted thiazol-2- yl)iminoethyl) phenyl ]hydrazono}-2-pyrazolin-5-one derivatives were synthesized by conventional and microwave methods. The synthesized compounds were tested for their antimicrobial activity against six strains of bacteria and three fungal strains. Compound 5a showed a broad spectrum of activity against bacteria and compound 5d exhibited excellent antifungal activity, while most of the other compounds showed varying antimicrobial activity.


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