A mixture of substituted quinoline-3yl-azomethines in dry dioxane containing pinch of anhydrous ZnCl2 and mercaptoacetic acid was refluxed for 8 h. The reaction mixture was cooled and poured into ice cold water. The solid was separated and filtered, dried and crystallized from ethanol solvent to get novel 4-thiazolidinone Derivatives. The synthesized compounds were characterized on the basis of satisfactory elemental analytical and spectral (IR, 1HNMR) data. Most of the compounds show excellent results when screened for their antimicrobial activity.
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