In our present research work, we have synthesized a series of β-carboline derivatives and evaluated for their anxiolytic activity. The structures of the compounds have been confirmed by IR and NMR spectroscopy. Newly synthesized compounds were tested for anxiolytic activity using elevated plus maze model. Among the synthesized compounds, N-(4-hydroxyphenyl)-9H-β-carboline-3-carboxamide (4a) was found to be most active with the maximum no. of entries in open arm and time spent in open arm.
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