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Synthesis and biological evaluation of dibenzo[b,f]azepine-5-carboxylic acid[1-(substituted-phenyl)-ethylidene]-hydrazides | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
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Abstract

Synthesis and biological evaluation of dibenzo[b,f]azepine-5-carboxylic acid[1-(substituted-phenyl)-ethylidene]-hydrazides

Author(s): Gopal Krishna Raoa*, Ranjit Kaur a, PN Sanjay Pai

A series of some new Schiff bases of Dibenzo[b,f]azepine-5-carboxylic acid[1-(substitutedphenyl)- ethylidene]-hydrazide (4a-j) were synthesized using various substituted aromatic ketones in absolute ethanol with few drops of glacial acetic acid as a catalyst. The structures were confirmed by their IR, and 1H NMR spectral and CHN analytical data. All the derivatives have been evaluated for their anti-bacterial activity by cup plate method and antitubercular activity by microbroth dilution method. Some of the derivatives have shown moderate to good biological activity.


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