Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Abstract

Synthesis and biological evaluation of new derivatives of tertiary thiazolamines

Author(s): Satish Koppireddi, Jayaram Reddy Komsani Ashok K. Tiwarib, Amtul Z. Ali, Rambabu Yadla

A series of new 4-(substitutedphenyl)-N,N-bis(4-(trifluoromethyl)benzyl)thiazol-2-amines (6a-j) and 4-(4- chlorophenyl)-N,N-bis(4-methoxybenzyl)thiazol-2-amines (7a-j) have been synthesized. All the newly synthesized compounds are characterized by IR, 1H NMR, 13C NMR and mass spectral studies. Compound 6h has shown promising α-glucosidase inhibitory activity, while compound 6j and 7f have displayed significant anticancer potential against neuroblastoma cells. Some of the targets have shown promising α-glucosidase inhibitory and anticancer activity.


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