Synthesis and Biological evaluation of Novel Triazolo-thiadiazole derivatives | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X


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Synthesis and Biological evaluation of Novel Triazolo-thiadiazole derivatives

Author(s): Anand Reddy, Suvarna G. Kini* and Muhammad Mubeen

We herein report the synthesis of some novel 4-(3-substituted [1,2,4] triazolo[3,4- b][1,3,4] thiadiazol-6-yl) derivatives. Condensation of the 4-amino-5-substituted-4H-1, 2, 4-triazole-3-thiols with aromatic acids in the presence of polyphosphoric acid (PPA) produced a series of 4-(3-substituted [1,2,4] triazolo[3,4- b][1,3,4]thiadiazol-6-yl) derivatives (TTDZ1-TTDZ27). The structure assigned to compounds was substantiated by their analytical and spectral data. These newly synthesized compounds have been screened for antibacterial, antioxidant and in-vitro anticancer activity.


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